Recently I've been experiencing intermittent issues in trying to use certain keystrokes in a few of my more common Windows-based applications. The two primary shortcuts I found that I cannot use are Ctrl-Shift-Home and Ctrl-Shift-End . These two shortcuts should highlight from the current cursor position to either the top or bottom of the available selection set, respectively. I checked all types of OS-level keyboard settings. After closing a few apps in an effort to reboot, I suddenly found I could use those keystrokes again! So I brought back up my apps . . . one at a time. The moment I reopened Opera, the keystrokes disabled. I tried disabling a lot of the various settings in Opera, one of which required a restart. I could not find a setting that gave me back these keystrokes. Strangely, Shift-Home and Shift-End both work. Ctrl-Home and Ctrl-End also both work. They just don't all work together. Additionally, all the Shift/Ctrl arrow keys also function fine.